GMP-Grade PAH for Auxiliary Medicinal Product Use
Basic Pharma manufactures Auxiliary Medicinal Products (AxMP) under Good Manufacturing Practice (GMP) guidelines. For example, the diagnostic agent Sodium 4-Aminohippurate (PAH) 2 g / 10 ml is specifically designed for use as an AxMP, serving as a vital component in medical and research protocols requiring precise kidney function assessment.
PAH in Renal Testing
Sodium 4-Aminohippurate (PAH) is a synthetic compound used to measure effective renal plasma flow (ERPF). After intravenous administration, PAH is almost completely cleared from blood by:
- Glomerular filtration: a small fraction is filtered.
- Active tubular secretion: most PAH is transported into urine via Organic Anion Transporters (OATs) in the proximal tubules.
Because clearance is highly efficient (~90–92%), nearly all PAH is removed in one kidney pass. Measuring PAH in plasma and urine, along with urine flow, allows precise ERPF calculation - critical for diagnosing kidney disease, monitoring function, and adjusting drug doses.
Expert Manufacturing for Every Clinical Trial Phase
Partner in IMP Development
Basic Pharma IMP develops and manufactures Investigational Medicinal Products (IMPs) under strict GMP conditions, ensuring safety, consistency, and reproducibility. We support clients from small-scale development through full clinical scale-up across diverse formulations, providing technical guidance throughout the development pathway.
GMP Certified
PAH for Accurate Renal Diagnostics
Our diagnostic agent Sodium 4‑Aminohippurate (PAH) 2 g / 10ml provides a reliable and accurate tool for measuring effective renal plasma flow (ERPF). Produced under strict GMP standards, it is available on request to support medical research protocols that require precise and consistent kidney function assessment.
FAQs
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No, PAH is an Auxiliary Medicinal Product (AxMP). Basic Pharma provides PAH for use in clinical trials.
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The minimum order quantity (MOQ) for PAH orders is 50 vials per order.
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Yes, PAH is shipped worldwide from our facility in the Netherlands.
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Upon request, Basic Pharma can provide an investigational Brochure (IB) and an Auxiliary Medicinal Product Dossier (AxMPD).
Services and Collaboration
Our IMP Department specializes in aseptic processing and filling of study medication for clinical trials. As part of the Basic Pharma group, we also offer quality control, contract manufacturing, and collaborate on product development and licensing. We regularly collaborate with partners to develop and license pharmaceutical products, making us a strong and versatile player in the pharmaceutical industry.
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More information about PAH
Explore more details about our PAH. Download the leaflet today and discover why it’s the right choice for your applications.
