Recombinant Histone H3
Basic Pharma Biotech produces recombinant Histone H3 through microbial fermentation in Escherichia coli.
Our recombinant Histone H3 is generated under stringent quality‑controlled conditions, ensuring consistent performance and contaminant‑free material suitable for research, diagnostic use, and early‑stage biopharmaceutical development.
We supply a single, well‑defined Histone H3 variant optimized for research, assay development, and analytical applications.
Why Choose Our Recombinant Histone H3?
Quality You Can Trust
Recombinant Histone H3, produced in E. coli, offers a high‑purity single variant compared to tissue‑derived histones, which often contain mixed forms.
Because Histone H3 is linked to cancer progression, sepsis, and inflammatory diseases, it serves as an important biomarker and research target. Our recombinant H3 is ideal for epigenetics and chromatin studies, cancer and sepsis research, antibody validation, assay development, and use as a reference standard.
- Singe, Homogeneous Variant - No Isoform Mixture
- Animal-Free and Free from Viral Contamination
- 95% purity verified by SDS-PAGE and HPLC
- Lyophilized powder for long-term stability and storage
- Manufactured in an EU-GMP Facility
- Every Batch Supplied with CoA
Core Principles Driving Quality and Global Reach
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Worldwide Shipping
Fast, reliable worldwide delivery. Receive your quote within one business day and we’ll ship your order the same day you confirm.
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Guaranteed Quality
Every product comes with a Certificate of Analysis for full transparency and trust.
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Missing Something? Contact Us!
If you can’t find what you need or have special (product) requests, our team is ready to help.
Product Specifications
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Product name
Recombinant Histone H3 Source
Bacteria – Escherichia coli Appearance
White grains/powder
Lyophilized from Buffer (25 mM HEPES + 140 mM NaCl)Packaging sizes
100 µg | 1 mg Purity
> 95% pure based on SDS PAGE Safety
No risk of animal derived contaminations (e.g. viral particles/pathogens) Storage conditions and Stability
Lyophilized (at least 6 months at -80 °C)
Reconstituted (typical 1 week @ 4 °C)Disclaimer
This product is for R&D and manufacturing purposes only. Not for direct therapeutic use. -
Number of Amino Acids
AA 1 – 136 (148 total, incl. Tag etc) Tag
6x Histidine Tag with Thrombin Cleavage Site Molecular weight
16760 Da Extinction Coefficient
4470 M-1 cm-1 Sequence
HHHHHHLVPR GSMARTKQTA RKSTGGKAPR KQLATKAARK SAPSTGGVKK PHRYRPGTVA LREIRRYQKS TELLIRKLPF QRLVREIAQD FKTDLRFQSA AIGALQEASE AYLVGLFEDT NLCAIHAKRV TIMPKDIQLA RRIRGERA
More information about our Histone H3
Want in-depth details like purity and linearity? Explore the full specifications. Download our Histone H3 leaflet today and discover why it’s the right choice for your applications
Learn More About Us!
Basic Pharma Biotech is more than a recombinant protein shop, we are your trusted partner in protein production and purification. From lab-scale to pilot-scale, we collaborate closely, think beyond standard solutions, and deliver scalable processes tailored to your research needs. Get in contact for more information.
Recombinant Histone H3
Controlled Experimental Systems
Histone H3 is a core nucleosomal protein involved in chromatin organization and gene regulation. The protein contains residues that are subject to methylation, acetylation and phosphorylation, which regulate transcriptional activity and cellular response mechanisms.
Recombinant Histone H3 expressed in Escherichia coli provides a homogeneous protein population. In contrast to tissue derived material, recombinant production ensures defined sequence composition and avoids isoform mixtures.
This supports controlled nucleosome assembly, antibody validation and analytical testing.
Production and Purification
Recombinant Histone H3 is produced through microbial fermentation followed by chromatography based purification. Each batch is manufactured according to predefined process parameters.
Identity and purity are verified prior to release. Manufacturing and testing are performed within our EU GMP facility.
Applications
Recombinant Histone H3 is used in:
- Chromatin and nucleosome assembly studies
- Epigenetics research
- Cancer and inflammation research
- Antibody validation
- Analytical assay development
For projects requiring defined composition and documented production, recombinant Histone H3 provides controlled input material.
Beyond Catalog Supply
In addition to supplying recombinant Histone H3, Basic Pharma Biotech develops and manufactures custom recombinant proteins. Our in house fermentation and purification capabilities allow us to support scale up and tailored production projects.
Contact us if you require modified variants, specific buffer conditions or larger quantities.