Accelerate the development and scale up the production of your biologicals
The need for non-animal-derived proteins is increasing due to both safety and practical reasons. Therefore, we are expanding our services to help you bring your recombinant protein development from lab scale to the early clinical phase.
We are working towards GMP compliance, drawing on our extensive experience providing pharma services. Along with our in-house QC, and method validation expertise, we can provide the infrastructure to support you in creating proteins for different purposes, including:
- Non-GMP or preclinical proteins for R&D and industrial purposes
- Partnerships to develop products for future GMP applications
As your partner, we can tailor all services to your specific needs, while respecting all relevant quality guidelines.
Now is the perfect time to get involved so we can grow together!
Upstream bioprocess development
We can culture microorganisms up to biosafety level 2 (BSL-2) in our facility that is designed to work safely with genetically modified organisms up to containment level ML-II.
Downstream protein purification
Our advanced downstream equipment provides us with many strategies to process your biomolecules. From developing an optimal purification scheme, to testing scale-up and performing purification, we can help you with the full process.
Upscaling and
production
Once your bioprocess has been developed, we can help you with upscaling and production of your protein so you can move to the next stages of testing. Take advantage of our laboratory services to ensure the quality of your final product, then we can perform lyophilization and fill & finish to your requirements.
Strain development
We can aid you in developing an optimal microbial strain to produce high-quality recombinant proteins in yeast or bacterial host strains, such as Pichia pastoris or Escherichia coli. Our expression screening support can help you to identify the best-performing clones to use for production.
Equipment
Our state-of-the-art biotech facility is well equipped for a broad range of microbial fermentation and purification strategies to support biological process development to first in human.
- Shaking incubators for flask cultures
- Bioreactors: 0.5 LT – 5 LT and 50 LT total volume
- High-speed centrifuge
- Bioprocess homogenizer, up to 1200 bars for cell lysis
- Chromatography systems: R&D and pilot scale
- Ultrafiltration: Tangential flow filtration (TFF) system
- Lyophilization
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Analytical equipment, including:
- HPLC
- Electrophoresis
- Absorbance plate reader (e.g., enzymatic analysis / Bradford assays)
We also have a large network of subcontractors that we can consult for additional services as necessary. We will manage all interactions to help with your project management.
